Apellis Pharmaceuticals Marks Year of Substantial Growth and Product Acceptance

Apellis Pharmaceuticals Marks Year of Substantial Growth and Product Acceptance$APLS

Apellis Pharmaceuticals, Inc., a biopharmaceutical company, has reported a significant conclusion to the year, with its preliminary US net product revenues reaching new heights. The company’s innovative products, SYFOVRE® (pegcetacoplan injection) and EMPAVELI® (pegcetacoplan), have been at the forefront of commercial success, particularly SYFOVRE®, which has become the leading treatment for geographic atrophy (GA) secondary to age-related macular degeneration.

The company’s flagship product, SYFOVRE®, has generated approximately $114 million in preliminary US net product revenues for the fourth quarter alone and $275 million for the entire year. This treatment has achieved a remarkable distribution, with around 160,000 doses, including commercial and sample vials, dispensed throughout 2023. It is estimated that a vast majority of treated GA patients have transitioned, indicating its strong acceptance within the medical community.

EMPAVELI®, another cornerstone treatment offered by Apellis, has also shown commendable performance with preliminary US net product revenues of about $24 million in the fourth quarter and $91 million for the full year. This product has sustained an impressive patient compliance rate of 97%. The introduction of the EMPAVELI Injector in October has been well-received, with a significant portion of existing patients and the majority of new patients opting for the on-body device that simplifies the self-administration process.

Cedric Francois, M.D., Ph.D., co-founder and chief executive officer of Apellis, has shared a positive outlook on the company’s direction, highlighting the increasing treatment effects over time, the flexible dosing of SYFOVRE®, and the profound impact of EMPAVELI® on patients’ lives. The company’s achievements in the commercial sector are noteworthy, and its leadership is poised to capitalize on this momentum in the forthcoming year.

SYFOVRE® stands out as the first and only approved therapy for GA that targets C3 to control the complement cascade, a crucial part of the body’s immune system. Similarly, EMPAVELI® is a targeted C3 therapy aimed at regulating the complement cascade to prevent the onset and progression of serious diseases, with approvals for the treatment of paroxysmal nocturnal hemoglobinuria (PNH) in the United States, European Union, and additional regions.

The safety of its products is a priority for Apellis. SYFOVRE® has specific contraindications for patients with ocular or periocular infections and those with active intraocular inflammation. It also carries risks of endophthalmitis and retinal detachments, which necessitate meticulous aseptic injection technique and immediate attention to any symptoms indicative of these conditions.

Apellis Pharmaceuticals, Inc. has exhibited a robust performance over the past year, with its pioneering treatments SYFOVRE® and EMPAVELI® securing a significant position in the healthcare market. The company’s commitment to enhancing patient outcomes through advanced therapies is reflected in its commercial achievements and the favorable reception of its products by the medical community. With a steadfast focus on safety and efficacy, Apellis is poised to continue its trajectory of growth and innovation in the medical field, addressing the needs of patients with serious diseases.2024-01-10T06:35:10.788Z

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